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A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides

Miller

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides Thumbnail


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Abstract

D-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Journal Article Type Article
Acceptance Date Sep 9, 2015
Publication Date Sep 9, 2015
Publicly Available Date Mar 29, 2024
Journal Organic & Biomolecular Chemistry
Print ISSN 1477-0520
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 13
Issue 46
Pages 11208-11219
DOI https://doi.org/10.1039/c5ob01706h
Publisher URL http://dx.doi.org/10.1039/c5ob01706h

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