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The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis.

The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis. Thumbnail


Abstract

To investigate the influence of HLA-DRB1 alleles encoding the QK/RRAA shared epitope (SE) on radiological outcome in rheumatoid arthritis (RA), and to determine whether it is modulated by alleles carrying the putative rheumatoid arthritis-protective (RAP) sequence DERAA. Patients and methods. The association between erosive damage and HLA-DRB1 status was examined in 315 RA patients with a disease duration of 5-30 yr. Radiological outcome was measured by scoring X-rays of the hands and feet using the standard radiographs of Larsen (Larsen score). HLA-DRB1 typing was carried out using polymerase chain reaction methodology.

Acceptance Date Jul 1, 1999
Publication Date Dec 1, 1999
Publicly Available Date Mar 29, 2024
Journal Rheumatology (Oxford)
Print ISSN 1462-0324
Publisher Oxford University Press
Pages 1221 - 1227
DOI https://doi.org/10.1093/rheumatology/38.12.1221
Keywords Rheumatoid arthritis, HLA-DRB1, Shared epitope, Protective alleles, Radiological outcome
Publisher URL http://rheumatology.oxfordjournals.org/content/38/12/1221.long

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