Mattey, DL and Hassell, AB and Plant, MJ and Cheung, NT and Dawes, PT and Jones, PW and Thomson, W and Poulton, KV and Hajeer, AH and Ollier, WE (1999) The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis. Rheumatology (Oxford), 38 (12). 1221 - 1227. ISSN 1462-0324

[img]
Preview
Text
The influence of HLA-DRB1 alleles encoding the DERAA amino acid motif on radiological outcome in rheumatoid arthritis (DMattey).pdf

Download (145kB) | Preview

Abstract

To investigate the influence of HLA-DRB1 alleles encoding the QK/RRAA shared epitope (SE) on radiological outcome in rheumatoid arthritis (RA), and to determine whether it is modulated by alleles carrying the putative rheumatoid arthritis-protective (RAP) sequence DERAA. Patients and methods. The association between erosive damage and HLA-DRB1 status was examined in 315 RA patients with a disease duration of 5-30 yr. Radiological outcome was measured by scoring X-rays of the hands and feet using the standard radiographs of Larsen (Larsen score). HLA-DRB1 typing was carried out using polymerase chain reaction methodology.

Item Type: Article
Uncontrolled Keywords: Rheumatoid arthritis, HLA-DRB1, Shared epitope, Protective alleles, Radiological outcome
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 27 Nov 2014 09:50
Last Modified: 08 Jun 2016 11:00
URI: http://eprints.keele.ac.uk/id/eprint/130

Actions (login required)

View Item View Item