Sirker, A and Mamas, M and Robinson, D and Anderson, S and Kinnaird, T and Stables, R and de belder, M and Ludman, P and Hildick-Smith, D (2015) Bivalirudin, glycoprotein inhibitor and heparin use and association with outcomes of primary percutaneous coronary intervention in the United Kingdom. European Heart Journal. ISSN 1522-9645
EHJ - UK antithrombotic paper_resubmit_1.docx - Accepted Version
Available under License Creative Commons Attribution.
The HORIZONS trial reported a survival advantage for bivalirudin over heparin-with-glycoprotein inhibitors (GPIs) in primary PCI for ST elevation myocardial infarction. This drove an international shift in clinical practice. Subsequent studies have produced divergent findings on mortality benefits with bivalirudin. We investigated this issue in a larger population than studied in any of these trials, using the United Kingdom national PCI registry. METHODS AND RESULTS: 61 136 primary PCI procedures were performed between January 2008 and January 2012. Demographic and procedural data were obtained from the registry. Mortality information was obtained through the UK Office of National Statistics. Multivariable logistic regression and propensity analysis modelling were utilized to study the association of different anti-thrombotic strategies with outcomes. Unadjusted data demonstrated near-identical survival curves for bivalirudin and heparin-plus-GPI groups. Significantly higher early and late mortality was found in patients treated with heparin alone (P < 0.0001) but this group had a markedly higher baseline risk. After propensity matching, the bivalirudin vs. heparin-plus-GPI groups still demonstrated very similar adjusted mortality (odds ratio 1.00 at 30 days, and 0.96 at 1 year). Patients treated with heparin alone continued to show higher mortality after adjustment, although effect size was considerably diminished (odds ratio vs. other groups 1.17-1.24 at 30 days). CONCLUSIONS: Analysis of recent UK data showed no significant difference in short- or medium-term mortality between ST elevation myocardial infarction patients treated with bivalirudin vs. heparin-plus-GPI at primary PCI.
|Uncontrolled Keywords:||Heparin, Bivalirudin, Glycoprotein inhibitor, Primary PCI, STEMI, Anti-thrombotic|
|Subjects:||R Medicine > R Medicine (General)|
|Divisions:||Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine|
|Date Deposited:||06 Jan 2016 11:52|
|Last Modified:||31 May 2016 10:59|
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