El Haj, AJ and Nessler, KHL and Henstock, JR and Waters, SL and Whiteley, JP (2016) The influence of hydrostatic pressure on tissue engineered bone development. Journal of Theoretical Biology. ISSN 1095-8541

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Abstract

The hydrostatic pressure stimulation of an appropriately cell–seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue external to the body. We propose a mathematical model, and employ a suite of candidate constitutive laws, to qualitatively describe the effect of applied hydrostatic pressure on the quantity of minerals deposited in such an experimental setup. By comparing data from numerical simulations with experimental observations under a number of stimulation protocols, we suggest that the response of bone cells to an applied pressure requires consideration of two components; i) a component describing the cell memory of the applied stimulation, and ii) a recovery component, capturing the time cells require to recover from high rates of mineralisation.

Item Type: Article
Additional Information: Published online ahead of print, 18 January 2016
Uncontrolled Keywords: modelling, tissue engineering, ordinary differential equation, biomechanical response
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 19 Jan 2016 11:25
Last Modified: 18 Jan 2017 01:30
URI: http://eprints.keele.ac.uk/id/eprint/1394

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