Maier, AG and Rug, M and O'Neill, MT and Brown, M and Chakravorty, S and Szestak, T and Chesson, J and Wu, Y and Hughes, K and Coppel, RL and Newbold, C and Beeson, JG and Craig, A and Crabb, BS and Cowman, AF (2008) Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell, 134 (1). 48 - 61. ISSN 0092-8674

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Abstract

A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the host cell. To understand these unique modifications, we used a large-scale gene knockout strategy combined with functional screens to identify proteins exported into parasite-infected erythrocytes and involved in remodeling these cells. Eight genes were identified encoding proteins required for export of the parasite adhesin PfEMP1 and assembly of knobs that function as physical platforms to anchor the adhesin. Additionally, we show that multiple proteins play a role in generating increased rigidity of infected erythrocytes. Collectively these proteins function as a pathogen secretion system, similar to bacteria and may provide targets for antivirulence based therapies to a disease responsible for millions of deaths annually.

Item Type: Article
Uncontrolled Keywords: Humdisease, Cellbio
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 25 Jan 2016 15:25
Last Modified: 31 May 2016 13:59
URI: http://eprints.keele.ac.uk/id/eprint/1411

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