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Critical overview of the benefits and harms of aspirin

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Abstract

Aspirin is widely used internationally for a variety of indications, with the most prominent one being that of cardiovascular disease. However, aspirin has also been proposed as a treatment option in a diverse range of conditions such as diabetes mellitus, cancer prevention, and obstetrics. In our overview, we critically appraise the current evidence from recent systematic reviews and meta-analyses covering the benefits of aspirin across these conditions. We also look at evidence that some patients may not derive benefit due to the concept of aspirin resistance. Aspirin is also associated with the potential for significant harm, principally from haemorrhagic adverse events. We critically appraise the threat of haemorrhagic complications, and weigh up these risks against that of any potential benefit.

Acceptance Date May 7, 2010
Publication Date May 14, 2010
Publicly Available Date Mar 28, 2024
Journal Pharmaceuticals
Publisher MDPI
Pages 1491 - 1506
DOI https://doi.org/10.3390/ph3051491
Keywords aspirin, efficacy, adverse events
Publisher URL https://doi.org/10.3390/ph3051491

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