Smith, D and Sovová, K and Dryahina, K and Doušová, T and Dřevínek, P and Španěl, P (2016) Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis. Journal of Breath Research, 10 (2). 021002 -?. ISSN 1752-7163

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Abstract

A study has been carried out of the volatile organic compounds present in the exhaled breath of 58 cystic fibrosis (CF) patients. An important observation is that the acetic acid vapour concentration measured by selected ion flow tube mass spectrometry (SIFT-MS) is significantly elevated in the exhaled breath of CF patients, independent of the Pseudomonas aeruginosa (PA) infection status (PA-infected median 170 ppbv; PA-negative median 182 ppbv), compared to that of healthy controls (median 48 ppbv). The cause for this may be decreased pH of the mucus lining the CF airways. Thus, we speculate that non-invasive measurement of breath acetic acid concentration could serve as an indicator of the acidity of the CF airways mucosa.

Item Type: Article
Additional Information: © The Authors, IOP Publishing; This is the author accepted manuscript of a paper published in final form as Smith, D. et al., 2016. Breath concentration of acetic acid vapour is elevated in patients with cystic fibrosis. Journal of Breath Research, 10(2), p.021002, available at: http://dx.doi.org/10.1088/1752-7155/10/2/021002
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 14 Jun 2016 09:52
Last Modified: 12 Jul 2017 08:50
URI: http://eprints.keele.ac.uk/id/eprint/1853

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