Smith, D and Španěl, P (2016) Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas. Bioanalysis, 8 (11). 1183 -1201. ISSN 1757-6199

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Abstract

This article reflects our observations of recent accomplishments made using selected ion flow tube MS (SIFT-MS). Only brief descriptions are given of SIFT-MS as an analytical method and of the recent extensions to the underpinning analytical ion chemistry required to realize more robust analyses. The challenge of breath analysis is given special attention because, when achieved, it renders analysis of other air media relatively straightforward. Brief overviews are given of recent SIFT-MS breath analyses by leading research groups, noting the desirability of detection and quantification of single volatile biomarkers rather than reliance on statistical analyses, if breath analysis is to be accepted into clinical practice. A 'strengths, weaknesses, opportunities and threats' analysis of SIFT-MS is made, which should help to increase its utility for trace gas analysis.

Item Type: Article
Additional Information: This is the accepted version of the paper published as Smith, D. & Španěl, P., 2016. Status of selected ion flow tube MS: accomplishments and challenges in breath analysis and other areas. Bioanalysis, 8(11), pp.1183–1201 available from http://dx.doi.org/10.4155/bio-2016-0038
Uncontrolled Keywords: SIFT-MS, SWOT analysis, breath analysis, cancer, cystic fibrosis, metabolites, real-time analysis, selected ion flow tube MS, small molecules, trace gas analysis, volatile organic compounds
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 14 Jun 2016 14:50
Last Modified: 23 May 2017 01:30
URI: http://eprints.keele.ac.uk/id/eprint/1854

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