Kishore, A, Vail, A, Bray, B, Chamorro, A, Di Napoli, M, Kalra, L, Langhorne, P, Montaner, J, Roffe, C, Rudd, A, Tyrrell, A, Van de Beek, D, Woodhead, M, Meisel, A and Smith, C (2016) Clinical risk scores for predicting stroke-associated pneumonia: A systematic review. European Stroke Journal, 1 (2). 76 - 84.

[img]
Preview
Text
C Roffe - Clinical risk scores for predicting stroke-associated pneumonia.pdf - Accepted Version
Available under License Creative Commons Attribution.

Download (111kB) | Preview

Abstract

Purpose
Several risk stratification scores for predicting stroke-associated pneumonia have been derived. We aimed to evaluate the performance and clinical usefulness of such scores for predicting stroke-associated pneumonia.

Method
A systematic literature review was undertaken in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, with application of the Quality Assessment of Diagnostic Accuracy-2 tool. Published studies of hospitalised adults with ischaemic stroke, intracerebral haemorrhage, or both, which derived and validated an integer-based clinical risk score, or externally validated an existing score to predict occurrence of stroke-associated pneumonia, were considered and independently screened for inclusion by two reviewers.

Findings
We identified nine scores, from eight derivation cohorts. Age was a component of all scores, and the NIHSS score in all except one. Six scores were internally validated and five scores were externally validated. The A2DS2 score (Age, Atrial fibrillation, Dysphagia, Severity [NIHSS], Sex) was the most externally validated in 8 independent cohorts. Performance measures were reported for eight scores. Discrimination tended to be more variable in the external validation cohorts (C statistic 0.67–0.83) than the derivation cohorts (C statistic 0.74–0.85).

Discussion
Overall, discrimination and calibration were similar between the different scores. No study evaluated influence on clinical decision making or prognosis.

Conclusion
The clinical prediction scores varied in their simplicity of use and were comparable in performance. Utility of such scores for preventive intervention trials and in clinical practice remains uncertain and requires further study.

Item Type: Article
Uncontrolled Keywords: pneumonia; ischaemic stroke; intracerebral haemorrhage; risk score
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 01 Sep 2016 08:37
Last Modified: 11 Apr 2019 08:38
URI: http://eprints.keele.ac.uk/id/eprint/2146

Actions (login required)

View Item View Item