Roberts, S, Turner, S and Evans, C (2016) Tissue Engineering of Fibrocartilaginous Tissues: The Intervertebral Disc and the Meniscus. Reference Module in Biomedical Sciences, 5. pp. 321-329.

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Abstract

The intervertebral disc in the spine and the meniscus in the knee are two fibrocartilaginous tissues which commonly are injured or become degenerate, causing significant clinical problems. The principals of tissue engineering, which are applicable elsewhere in the body, hold true for the disc and meniscus. Whilst there are some similarities with articular cartilage in terms of the molecules present, these fibrocartilages have their own peculiarities, some of which can be quite challenging. Following a description of the structure and anatomy of the disc and meniscus and the current clinical treatments, the different strategies for biological repair are described focusing particularly on cell therapy. The types of cells and scaffolds being investigated and how these can be modified are discussed.

Item Type: Article
Uncontrolled Keywords: back pain; cell therapy; clinical applications; collagens; meniscal injury; proteoglycans; regenerative medicine; scaffolds
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 08 Sep 2016 08:45
Last Modified: 09 Apr 2019 08:37
URI: http://eprints.keele.ac.uk/id/eprint/2166

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