Toh, WS and Brittberg, M and Farr, J and Foldager, CB and Gomoll, AH and Hui, JH and Richardson, JB and Roberts, S and Spector, M (2016) Cellular senescence in aging and osteoarthritis. Acta Orthop. 1 - 9. ISSN 1745-3682

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Abstract

- It is well accepted that age is an important contributing factor to poor cartilage repair following injury, and to the development of osteoarthritis. Cellular senescence, the loss of the ability of cells to divide, has been noted as the major factor contributing to age-related changes in cartilage homeostasis, function, and response to injury. The underlying mechanisms of cellular senescence, while not fully understood, have been associated with telomere erosion, DNA damage, oxidative stress, and inflammation. In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 20 Oct 2016 08:57
Last Modified: 20 Oct 2016 08:57
URI: http://eprints.keele.ac.uk/id/eprint/2297

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