Mamas, MA ORCID: https://orcid.org/0000-0001-9241-8890, Kwok, CS ORCID: https://orcid.org/0000-0001-7047-1586, Kontopantelis, E, Fryer, AA, Buchan, I, Bachmann, MO, Zaman, MJ and Myint, PK (2016) Relationship between anemia and mortality outcomes in a national ACS cohort: insights from the UK MINAP registry. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 5 (11).

[img]
Preview
Text
mamas_2016_JAHA_REF.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial.

Download (347kB) | Preview

Abstract

Background
We aim to determine the prevalence of anemia in acute coronary syndrome (ACS) patients and compare their clinical characteristics, management, and clinical outcomes to those without anemia in an unselected national ACS cohort.

Methods and Results
The Myocardial Ischemia National Audit Project (MINAP) registry collects data on all adults admitted to hospital trusts in England and Wales with diagnosis of an ACS. We conducted a retrospective cohort study by analyzing patients in this registry between January 2006 and December 2010 and followed them up until August 2011. Multiple logistic regressions were used to determine factors associated with anemia and the adjusted odds of 30‐day mortality with 1 g/dL incremental hemoglobin increase and the 30‐day and 1‐year mortality for anemic compared to nonanemic groups. Analyses were adjusted for covariates. Our analysis of 422 855 patients with ACS showed that 27.7% of patients presenting with ACS are anemic and that these patients are older, have a greater prevalence of renal disease, peripheral vascular disease, diabetes mellitus, and previous acute myocardial infarction, and are less likely to receive evidence‐based therapies shown to improve clinical outcomes. Finally, our analysis suggests that anemia is independently associated with 30‐day (OR 1.28, 95% CI 1.22‐1.35) and 1‐year mortality (OR 1.31, 95% CI 1.27‐1.35), and we observed a reverse J‐shaped relationship between hemoglobin levels and mortality outcomes.

Conclusions
The prevalence of anemia in a contemporary national ACS cohort is clinically significant. Patients with anemia are older and multimorbid and less likely to receive evidence‐based therapies shown to improve clinical outcomes, with the presence of anemia independently associated with mortality outcomes.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via American Heart Association at https://doi.org/10.1161/JAHA.116.003348 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: acute coronary syndrome, anemia, mortality
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 26 Oct 2016 08:14
Last Modified: 04 Apr 2019 12:44
URI: http://eprints.keele.ac.uk/id/eprint/2347

Actions (login required)

View Item View Item