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Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study

Dou, Yanna; Sun, Xiran; Liu, Dong; Zhang, Li; Xiao, Jing; Cheng, Genyang; Yu, Dahai; Zhao, Zhanzheng

Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study Thumbnail


Authors

Yanna Dou

Xiran Sun

Dong Liu

Li Zhang

Jing Xiao

Genyang Cheng

Zhanzheng Zhao



Abstract

Background
Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR (mGFR) and estimated GFR (eGFR). One of the mGFR was 99mTc-DTPA scintigraphy method and eGFR using GFR equations were used clinically. Equations were modification of diet in renal disease (MDRD), chronic kidney disease epidemiology collaboration (CKD-EPI), and Chinese adapted MDRD (C-MDRD). This study assessed the accuracy of three different equations for estimated glomerular filtration rate (eGFR) with mGFR using DTPA scintigraphy method as the standard in a population of Chinese chronic kidney disease patients at the G3a stage.

Results
One hundred and twenty-two patients (age 52.0 ± 15.6 years, 69 were male) were determined as CKD stage 3 based on mGFR. Patients were divided into G3a (47 patients) and G3b (75 patients) subgroups. Bias between eGFR for CKD-EPI and reference mGFR was 0.92 mL/min and 95% limits of agreement was -38.82 to 40.67 mL/min. Bias between eGFR for C-MDRD and mGFR was 3.76 and 95% limits of agreement was -39.32 to 46.85 mL/min. Bias between eGFR for MDRD and mGFR was 3.53 and 95% limits of agreement was -43.35 to 50.4 mL/min. The CKD-EPI equation showed better diagnostic value with a greater area under the receiver operating characteristic curve (AUC: 0.763). AUC for MDRD and C-MDRD were 0.75 and 0.757, respectively.

Conclusions
There were no obvious advantages in accuracy, sensitivity, and specificity for the diagnosis of patients at the G3a stage using the CKD-EPI equation.

Journal Article Type Article
Acceptance Date Jan 24, 2017
Publication Date Feb 24, 2017
Publicly Available Date Mar 29, 2024
Journal BMC Research Notes
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 10
Article Number 107
DOI https://doi.org/10.1186/s13104-017-2400-8
Keywords G3a stage, Glomerular filtration rate equations, Accuracy, Chronic kidney disease, Biochemistry, Genetics, Molecular Biology, Medicine
Publisher URL https://doi.org/10.1186/s13104-017-2400-8
PMID 28235417

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