Dutta, R and Ball, H and Siribaddana, S and Sumathipala, A and Samaraweera, S and McGuffin, P and Hotopf, M (2017) Genetic and other risk factors for suicidal ideation and the relationship with depression. Psychological Medicine. ISSN 0033-2917

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Abstract

There is a genetic contribution to the risk of suicide, but sparse prior research on the genetics of suicidal ideation.
Active and passive suicidal ideation were assessed in a Sri Lankan population-based twin registry (n = 3906 twins) and a matched non-twin sample (n = 2016). Logistic regression models were used to examine associations with socio-demographic factors, environmental exposures and psychiatric symptoms. The heritability of suicidal ideation was assessed using structural equation modelling.
The lifetime prevalence of any suicidal ideation was 13.0% (11.7–14.3%) for men; 21.8% (20.3–23.2%) for women, with no significant difference between twins and non-twins. Factors that predicted suicidal ideation included female gender, termination of marital relationship, low education level, urban residence, losing a parent whilst young, low standard of living and stressful life events in the preceding 12 months. Suicidal ideation was strongly associated with depression, but also with abnormal fatigue and alcohol and tobacco use. The best fitting structural equation model indicated a substantial contribution from genetic factors (57%; CI 47–66) and from non-shared environmental factors (43%; CI 34–53) in both men and women. In women this genetic component was largely mediated through depression, but in men there was a significant heritable component to suicidal ideation that was independent of depression.
These are the first results to show a genetic contribution to suicidal ideation that is independent of depression outside of a high-income country. These phenomena may be generalizable, because previous research highlights similarities between the aetiology of mental disorders in Sri Lanka and higher-income countries.

Item Type: Article
Additional Information: This article has been published in a revised form in Psychological Medicine http://dx.doi.org/10.1017/s0033291717000940. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder.
Uncontrolled Keywords: depression, genetics, suicidal ideation, twin study
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 17 Mar 2017 09:37
Last Modified: 17 May 2017 09:10
URI: http://eprints.keele.ac.uk/id/eprint/3032

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