Jelenkovic, A and Hur, Y-M and Sund, R and Yokoyama, Y and Siribaddana, SH and Hotopf, M and Sumathipala, A and Rijsdijk, F and Tan, Q and Zhang, D and Pang, Z and Aaltonen, S and Heikkilä, K and Öncel, SY and Aliev, F and Rebato, E and Tarnoki, AD and Tarnoki, DL and Christensen, K and Skytthe, A and Kyvik, KO and Silberg, JL and Eaves, LJ and Maes, HH and Cutler, TL and Hopper, JL and Ordoñana, JR and Sánchez-Romera, JF and Colodro-Conde, L and Cozen, W and Hwang, AE and Mack, TM and Sung, J and Song, Y-M and Yang, S and Lee, K and Franz, CE and Kremen, WS and Lyons, MJ and Busjahn, A and Nelson, TL and Whitfield, KE and Kandler, C and Jang, KL and Gatz, M and Butler, DA and Stazi, MA and Fagnani, C and D'Ippolito, C and Duncan, GE and Buchwald, D and Derom, CA and Vlietinck, RF and Loos, RJ and Martin, NG and Medland, SE and Montgomery, GW and Jeong, H-U and Swan, GE and Krasnow, R and Magnusson, PK and Pedersen, NL and Dahl-Aslan, AK and McAdams, TA and Eley, TC and Gregory, AM and Tynelius, P and Baker, LA and Tuvblad, C and Bayasgalan, G and Narandalai, D and Lichtenstein, P and Spector, TD and Mangino, M and Lachance, G and Bartels, M and van Beijsterveldt, TC and Willemsen, G and Burt, SA and Klump, KL and Harris, JR and Brandt, I and Nilsen, TS and Krueger, RF and McGue, M and Pahlen, S and Corley, RP and Hjelmborg, JVB and Goldberg, JH and Iwatani, Y and Watanabe, M and Honda, C and Inui, F and Rasmussen, F and Huibregtse, BM and Boomsma, DI and Sørensen, TIA and Kaprio, J and Silventoinen, K (2016) Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994. Elife, 5. ISSN 2050-084X

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Abstract

Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 1886-1994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.

Item Type: Article
Subjects: ?? CODATwins project ??
R Medicine > RA Public aspects of medicine
?? birth cohorts ??
?? height ??
?? heritability ??
?? human ??
?? human biology ??
?? medicine ??
?? twins ??
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 21 Mar 2017 09:59
Last Modified: 21 Mar 2017 09:59
URI: http://eprints.keele.ac.uk/id/eprint/3042

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