Jenkins, SI, Yiu, HH, Rosseinsky, MJ and Chari, DM (2014) Magnetic nanoparticles for oligodendrocyte precursor cell transplantation therapies: progress and challenges. Molecular and Cellular Therapies, 2 (23).

[img]
Preview
Text
jenkins_2014.pdf - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview

Abstract

Oligodendrocyte precursor cells (OPCs) have shown high promise as a transplant population to promote regeneration in the central nervous system, specifically, for the production of myelin - the protective sheath around nerve fibers. While clinical trials for these cells have commenced in some areas, there are currently key barriers to the translation of neural cell therapies. These include the ability to (a) image transplant populations in vivo; (b) genetically engineer transplant cells to augment their repair potential; and (c) safely target cells to sites of pathology. Here, we review the evidence that magnetic nanoparticles (MNPs) are a 'multifunctional nanoplatform' that can aid in safely addressing these translational challenges in neural cell/OPC therapy: by facilitating real-time and post-mortem assessment of transplant cell biodistribution, and biomolecule delivery to transplant cells, as well as non-invasive 'magnetic cell targeting' to injury sites by application of high gradient fields. We identify key issues relating to the standardization and reporting of physicochemical and biological data in the field; we consider that it will be essential to systematically address these issues in order to fully evaluate the utility of the MNP platform for neural cell transplantation, and to develop efficacious neurocompatible particles for translational applications.

Item Type: Article
Uncontrolled Keywords: OPC, uptake, labeling, tracking, iron oxide, magnetic targeting, neural cell, cell therapy
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 27 Feb 2015 09:14
Last Modified: 20 May 2019 08:24
URI: http://eprints.keele.ac.uk/id/eprint/305

Actions (login required)

View Item View Item