Bendtsen, M, Bunger, C, Colombier, P, Le Visage, C, Roberts, S, Sakai, D and Urban, JPG (2016) Biological challenges for regeneration of the degenerated disc using cellular therapies. Acta Orthopaedica, 87 (sup363). 39 -46.

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Abstract

In this review, we discuss some of the challenges in successful cellular repair of the disc. We fi rst review the function, organization, and composition of a normal disc, outline the changes that occur in degeneration, and consider how these might infl uence function. We then summarize cell therapy approaches to repairing the disc in relation to the choice of cells and cell support. We outline the challenges facing the implanted cells in the degenerate disc, and ask whether these therapies can be evaluated in animal models. Finally, we outline the important, but often neglected, problem of patient selection.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 28 Apr 2017 08:18
Last Modified: 03 Apr 2019 10:41
URI: http://eprints.keele.ac.uk/id/eprint/3307

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