Carroll, WD and Lenney, W and Jones, PW and Strange, RC and Child, F and Whyte, MK and Primhak, RA and Fryer, AA (2005) Effects of glutathione S-transferase M1, T1 and P1 on lung function in asthmatic families. Clinical and Experimental Allergy, 35 (9). 1155 - 1161. ISSN 1365-2222

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Abstract

RATIONALE: Previous data have suggested that glutathione-S-transferase (GST) genotypes are important in determining the rate of lung function growth in childhood. This effect was most marked in Caucasian children with asthma. OBJECTIVES: We investigated the association of lung function with GSTM1, GSTP1 and GSTT1 genotypes in Caucasian families with asthma. METHODS: Four hundred and eighteen children and 316 parents from 224 Caucasian families were recruited via a child with asthma, the proband. Associations between lung function and GST genotype were determined using multilevel models. RESULTS: There were no observed associations between lung function and GST genotype in parents. However, in the children, the GSTP1 val(105)/val(105) and GSTM1 null genotypes were associated with significantly higher forced expiratory volume in 1 s (FEV(1)) and FVC values as percentage of predicted. This effect was not statistically significant in the probands but was marked in their siblings in whom GSTP1 val(105)/val(105) was associated with 9.4% higher FEV(1) and 10.7% higher FVC (P=0.005 and 0.001, respectively). The GSTM1 null genotype was associated with a 6.7% higher FEV(1) and 4.1% higher FVC (P=0.003 and 0.063, respectively). These effects remained significant after correcting for the confounders of individual atopic status, tobacco smoke exposure and familial aggregation of lung function values. CONCLUSIONS: GSTM1 and GSTP1 genotypes are important determinants of lung function in childhood. The smaller differences seen in probands are predicted by a simple model in which more rapid decline in lung function is seen in these individuals.

Item Type: Article
Additional Information: © 1999 - 2017 John Wiley & Sons, Inc. All Rights Reserved
Subjects: ?? Adolescent ??
?? Adult ??
?? Asthma ??
?? Child ??
?? England ??
?? European Continental Ancestry Group ??
?? Female ??
?? Forced Expiratory Volume ??
?? Genotype ??
?? Glutathione Transferase ??
?? Homozygote ??
?? Humans ??
?? Isoenzymes ??
?? Linear Models ??
?? Lung ??
?? Male ??
?? Middle Aged ??
?? Parents ??
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system
R Medicine > RJ Pediatrics
?? Siblings ??
?? Vital Capacity ??
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 05 Jun 2017 14:56
Last Modified: 05 Jun 2017 14:56
URI: http://eprints.keele.ac.uk/id/eprint/3387

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