Hariprakash, S and Alexander, J and Carroll, W and Ramesh, P and Randell, T and Turnbull, F and Lenney, W (2003) Randomized controlled trial of nebulized adrenaline in acute bronchiolitis. Pediatric Allergy and Immunology, 14 (2). 134 - 139. ISSN 0905-6157

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Abstract

Use of both l-epinephrine and racemic epinephrine (adrenaline) has improved clinical symptoms and composite respiratory scores in acute bronchiolitis. The objective of this randomized double-blind placebo-controlled study was to assess whether there was sufficient improvement in clinical state to reduce hospital admissions. Seventy-five infants aged 1 month to 1 year with a clinical diagnosis of acute bronchiolitis were treated with either 2 ml of 1:1000 nebulized adrenaline or 2 ml of nebulized normal saline administered after baseline assessment and 30 min later. Clinical respiratory parameters were recorded at 15-min intervals for a period of 2 h following the baseline assessment. Admission to hospital was the primary end-point and changes in respiratory parameters were secondary end-points. Fifty percent (19/38) of infants treated with adrenaline were discharged home compared with 38 percent (14/37) of those treated with saline. This 12 percent reduction in rate of admission is not statistically significant (95% CI of difference: -10% to 35%). There was no difference between treated and placebo groups in respiratory rate, oxygen saturation, heart rate or a composite respiratory distress score at 30, 60 or 120 min post-treatment. In this study, nebulized epinephrine did not confer a significant advantage over nebulized saline in the emergency room treatment of acute bronchiolitis.

Item Type: Article
Additional Information: © 1999 - 2017 John Wiley & Sons, Inc. All Rights Reserved
Subjects: ?? Acute Disease ??
?? Administration, Inhalation ??
?? Bronchiolitis ??
?? Bronchodilator Agents ??
?? Double-Blind Method ??
?? Emergency Service, Hospital ??
?? Epinephrine ??
?? Hospitalization ??
?? Humans ??
?? Infant ??
?? Nebulizers and Vaporizers ??
R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC705 Diseases of the respiratory system
R Medicine > RJ Pediatrics
?? Racepinephrine ??
?? Sodium Chloride ??
?? United Kingdom ??
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 05 Jun 2017 15:01
Last Modified: 05 Jun 2017 15:01
URI: http://eprints.keele.ac.uk/id/eprint/3388

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