Kitt, H and Lenney, W and Gilchrist, FJ (2016) Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis. BMC Pharmacology and Toxicology, 17. 14 - ?. ISSN 2050-6511

[img]
Preview
Text
Two case reports of the successful eradication of new isolates of Burkholderia cepacia complex in children with cystic fibrosis.pdf - Published Version
Available under License Creative Commons Attribution.

Download (425kB) | Preview

Abstract

BACKGROUND: Chronic infection with Burkholderia cepacia complex (BCC) has a detrimental effect on morbidity and mortality for patients with cystic fibrosis (CF). It is therefore logical to attempt to eradicate new isolates however there is a paucity of information to guide treatment. We report the successful eradication of new isolates of BCC in two children with CF. CASE PRESENTATION: Burkholderia cepacia was successfully eradicated in a 14 year old boy with CF and Burkholderia gladioli was successfully eradicated in a six year old girl with CF. In both children two weeks of intravenous (IV) tobramycin, ceftazidime and temocillin were used followed by three months of inhaled tobramycin. Bronchoalveolar lavage samples taken during flexible bronchoscopy were used prior to treatment to exclude spontaneous clearance as well as after treatment to confirm eradication. CONCLUSIONS: New isolates of BCC can be successfully eradicated in children with CF. More research is urgently required in this area to identify the best treatment regimen for BCC eradication.

Item Type: Article
Uncontrolled Keywords: Burkholderia cepacia complex; Cystic fibrosis; Eradication; Paediatrics
Subjects: ?? Administration, Inhalation ??
?? Adolescent ??
?? Anti-Bacterial Agents ??
?? Bronchoalveolar Lavage Fluid ??
?? Burkholderia Infections ??
?? Burkholderia cepacia complex ??
?? Ceftazidime ??
?? Child ??
?? Cystic Fibrosis ??
?? Cystic fibrosis ??
?? Drug Resistance, Multiple, Bacterial ??
?? Drug Therapy, Combination ??
?? England ??
?? Eradication ??
?? Female ??
?? Humans ??
?? Infusions, Intravenous ??
?? Male ??
?? Microbial Sensitivity Tests ??
?? Paediatrics ??
?? Penicillins ??
R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
?? Tobramycin ??
?? Treatment Outcome ??
Divisions: Faculty of Medicine and Health Sciences > Institute for Applied Clinical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 11 May 2017 12:38
Last Modified: 11 May 2017 12:38
URI: http://eprints.keele.ac.uk/id/eprint/3407

Actions (login required)

View Item View Item