Abhishek, A and Roddy, E and Doherty, M (2017) Gout - a guide for the general and acute physicians. Clinical Medicine (London), 17 (1). 54 - 59. ISSN 1473-4893

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Abstract

Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase - eg allopurinol, febuxostat - or by increasing the renal excretion of uric acid. Of these, xanthine oxidase inhibitors are used first line and are effective in 'curing' gout in the vast majority of patients. Gout can be diagnosed on clinical grounds in those with typical podagra. However, in those with involvement of other joints, joint aspiration is recommended to demonstrate monosodium urate crystals and exclude other causes of acute arthritis, such as septic arthritis. However, a clinical diagnosis of gout can be made if joint aspiration is not feasible. This review summarises the current understanding of the pathophysiology, clinical presentation, investigations and treatment of gout.

Item Type: Article
Additional Information: © Royal College of Physicians 2017. All rights reserved.
Uncontrolled Keywords: colchicine; gout; hyperuricemia; tophi; urate-lowering treatment
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
?? colchicine ??
?? gout ??
?? hyperuricemia ??
?? tophi ??
?? urate-lowering treatment ??
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 17 May 2017 10:25
Last Modified: 17 May 2017 10:25
URI: http://eprints.keele.ac.uk/id/eprint/3453

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