Bogl, LH and Jelenkovic, A and Vuoksimaa, E and Ahrenfeldt, L and Pietiläinen, KH and Stazi, MA and Fagnani, C and D'Ippolito, C and Hur, Y-M and Jeong, H-U and Silberg, JL and Eaves, LJ and Maes, HH and Bayasgalan, G and Narandalai, D and Cutler, TL and Kandler, C and Jang, KL and Christensen, K and Skytthe, A and Kyvik, KO and Cozen, W and Hwang, AE and Mack, TM and Derom, CA and Vlietinck, RF and Nelson, TL and Whitfield, KE and Corley, RP and Huibregtse, BM and McAdams, TA and Eley, TC and Gregory, AM and Krueger, RF and McGue, M and Pahlen, S and Willemsen, G and Bartels, M and van Beijsterveldt, TCEM and Pang, Z and Tan, Q and Zhang, D and Martin, NG and Medland, SE and Montgomery, GW and Hjelmborg, JVB and Rebato, E and Swan, GE and Krasnow, R and Busjahn, A and Lichtenstein, P and Öncel, SY and Aliev, F and Baker, LA and Tuvblad, C and Siribaddana, SH and Hotopf, M and Sumathipala, A and Rijsdijk, F and Magnusson, PKE and Pedersen, NL and Aslan, AKD and Ordoñana, JR and Sánchez-Romera, JF and Colodro-Conde, L and Duncan, GE and Buchwald, D and Tarnoki, AD and Tarnoki, DL and Yokoyama, Y and Hopper, JL and Loos, RJF and Boomsma, DI and Sørensen, TIA and Silventoinen, K and Kaprio, J (2017) Does the sex of one's co-twin affect height and BMI in adulthood?: A study of dizygotic adult twins from 31 cohorts. Biology of Sex Differences, 8. 14 - ?. ISSN 2042-6410

Does the sex of one's co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts.pdf - Published Version
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BACKGROUND: The comparison of traits in twins from opposite-sex (OS) and same-sex (SS) dizygotic twin pairs is considered a proxy measure of prenatal hormone exposure. To examine possible prenatal hormonal influences on anthropometric traits, we compared mean height, body mass index (BMI), and the prevalence of being overweight or obese between men and women from OS and SS dizygotic twin pairs. METHODS: The data were derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) database, and included 68,494 SS and 53,808 OS dizygotic twin individuals above the age of 20 years from 31 twin cohorts representing 19 countries. Zygosity was determined by questionnaires or DNA genotyping depending on the study. Multiple regression and logistic regression models adjusted for cohort, age, and birth year with the twin type as a predictor were carried out to compare height and BMI in twins from OS pairs with those from SS pairs and to calculate the adjusted odds ratios and 95% confidence intervals for being overweight or obese. RESULTS: OS females were, on average, 0.31 cm (95% confidence interval (CI) 0.20, 0.41) taller than SS females. OS males were also, on average, taller than SS males, but this difference was only 0.14 cm (95% CI 0.02, 0.27). Mean BMI and the prevalence of overweight or obesity did not differ between males and females from SS and OS twin pairs. The statistically significant differences between OS and SS twins for height were small and appeared to reflect our large sample size rather than meaningful differences of public health relevance. CONCLUSIONS: We found no evidence to support the hypothesis that prenatal hormonal exposure or postnatal socialization (i.e., having grown up with a twin of the opposite sex) has a major impact on height and BMI in adulthood.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via BioMed Central at - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Body mass index, CODATwins, Height, Opposite-sex twins, Prenatal hormone exposure
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 22 May 2017 10:49
Last Modified: 18 Jul 2017 15:13

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