Linhart, C, Talasz, H, Morandi, E, Exley, C ORCID: https://orcid.org/0000-0002-5116-7607, Lindner, H, Taucher, S, Egle, D, Hubalek, M, Concin, N and Ulmer, H (2017) Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine, 21. pp. 79-85.

[img]
Preview
Text
C Exley - Use of underarm cosmetic products in relation to risk of breast cancer.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (520kB) | Preview

Abstract

Background
Previous studies on breast cancer (BC), underarm cosmetic products (UCP) and aluminum salts have shown conflicting results. We conducted a 1:1 age-matched case-control study to investigate the risk for BC in relation to self-reported UCP application.

Methods
Self-reported history of UCP use was compared between 209 female BC patients (cases) and 209 healthy controls. Aluminum concentration in breast tissue was measured in 100 cases and 52 controls. Multivariable conditional logistic regression analysis was performed to estimate odds ratios (ORs) with 95% confidence intervals (CIs), adjusting for established BC risk factors.

Findings
Use of UCP was significantly associated with risk of BC (p = 0.036). The risk for BC increased by an OR of 3.88 (95% CI 1.03–14.66) in women who reported using UCP's several times daily starting at an age earlier than 30 years. Aluminum in breast tissue was found in both cases and controls and was significantly associated to self-reported UCP use (p = 0.009). Median (interquartile) aluminum concentrations were significantly higher (p = 0.001) in cases than in controls (5.8, 2.3–12.9 versus 3.8, 2.5–5.8 nmol/g).

Interpretation
Frequent use of UCPs may lead to an accumulation of aluminum in breast tissue. More than daily use of UCPs at younger ages may increase the risk of BC.

Item Type: Article
Uncontrolled Keywords: Underarm cosmetic products, Aluminum, Breast cancer, Case-control study, Epidemiology
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Symplectic
Date Deposited: 07 Jun 2017 08:41
Last Modified: 20 Mar 2019 09:47
URI: http://eprints.keele.ac.uk/id/eprint/3558

Actions (login required)

View Item View Item