Misirli, G and Hallinan, J and Röttger, R and Baumbach, J and Wipat, A (2014) BacillusRegNet: a transcriptional regulation database and analysis platform for Bacillus species. Journal of integrative bioinformatics, 11 (2). 244 - ?. ISSN 1613-4516

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Abstract

As high-throughput technologies become cheaper and easier to use, raw sequence data and corresponding annotations for many organisms are becoming available. However, sequence data alone is not sufficient to explain the biological behaviour of organisms, which arises largely from complex molecular interactions. There is a need to develop new platform technologies that can be applied to the investigation of whole-genome datasets in an efficient and cost-effective manner. One such approach is the transfer of existing knowledge from well-studied organisms to closely-related organisms. In this paper, we describe a system, BacillusRegNet, for the use of a model organism, Bacillus subtilis, to infer genome-wide regulatory networks in less well-studied close relatives. The putative transcription factors, their binding sequences and predicted promoter sequences along with annotations are available from the associated BacillusRegNet website (http://bacillus.ncl.ac.uk).

Item Type: Article
Uncontrolled Keywords: Algorithms, Bacillus subtilis, Binding Sites, Computational Biology, Computer Simulation, Computer Systems, Databases, Genetic, Databases, Protein, Gene Expression Regulation, Bacterial, Gene Regulatory Networks, Genome, Bacterial, High-Throughput Nucleotide Sequencing, Promoter Regions, Genetic, Software, Systems Biology, Transcription Factors, Transcription, Genetic
Subjects: ?? Algorithms ??
?? Bacillus subtilis ??
?? Binding Sites ??
?? Computational Biology ??
?? Computer Simulation ??
?? Computer Systems ??
?? Databases, Genetic ??
?? Databases, Protein ??
?? Gene Expression Regulation, Bacterial ??
?? Gene Regulatory Networks ??
?? Genome, Bacterial ??
?? High-Throughput Nucleotide Sequencing ??
?? Promoter Regions, Genetic ??
?? Software ??
?? Systems Biology ??
?? Transcription Factors ??
?? Transcription, Genetic ??
Divisions: Faculty of Natural Sciences > School of Computing and Maths
Related URLs:
Depositing User: Symplectic
Date Deposited: 16 Jun 2017 14:42
Last Modified: 11 Jul 2017 11:26
URI: http://eprints.keele.ac.uk/id/eprint/3641

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