Merrick, CJ and Kwok, CK (2017) G-quadruplexes: prediction, characterization, and biological application. Trends in Biotechnology, 35 (10). pp. 997-1013. ISSN 1879-3096

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Submitted 8.4.17 TIBTECH-S-17-00098.1.pdf - Accepted Version
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Abstract

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.tibtech.2017.06.012 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Nucleic acid structure; G-quadruplex; cell imaging; next-generation sequencing; aptamer; biosensing
Subjects: Q Science > QH Natural history
Divisions: Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 10 Jul 2017 09:25
Last Modified: 26 Jul 2018 01:30
URI: http://eprints.keele.ac.uk/id/eprint/3745

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