Malekigorji, M and Alfahad, M and Kong Thoo Lin, P and Jones, S and Curtis, ADM and Hoskins, C (2017) Thermally Triggered Theranostics for Pancreatic Cancer Therapy. Nanoscale, 9 (34). ISSN 2040-3372

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Abstract

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation reverses drug binding. This study exploits the reversible binding of novel polyamine based drugs in order to provide specific and effective method for pancreatic cancer treatment. Here we used novel bisnaphthalamido (BNIP) based drug series. Our hybrid nanoparticles (50 nm) were capable of drug loading onto their surface (3:1:0.25, Drug:Fe:Au). By exploiting the surface-to-drug electrostatic interaction of a range of BNIP agents, heat triggered drug release was achieved. 12-fold reduction in IC50 after 24 h in vitro and 5-fold reduction of tumour retardation in vivo compared with free drug in pancreatic models after treatment with the HNP-formulation and laser irradiation. This heat activated system could provide a key platform for future therapy strategies.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) will be available online via Royal Society of Chemistry at https://doi.org/10.1039/C7NR02751F - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: theranostic, pancreatic cancer, thermo-responsive drug delivery, laser irradiation
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 31 Jul 2017 15:57
Last Modified: 14 Sep 2017 14:11
URI: http://eprints.keele.ac.uk/id/eprint/3874

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