Martinez, CS and Escobar, AG and Uranga-Ocio, JA and Peçanha, FM and Vassallo, DV and Exley, C and Miguel, M and Wiggers, GA (2017) Aluminum Exposure for 60 days at Human Dietary Levels Impairs Spermatogenesis and Sperm Quality in Rats. Reproductive Toxicology. -. ISSN 0890-6238

[img] Text
exley_18082017.pdf - Accepted Version
Restricted to Repository staff only until 18 August 2018.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (3MB)

Abstract

Abstract Concerns about environmental aluminum (Al) and reproductive health have been raised. We investigated the effects of Al exposure at a human relevant dietary level and a high level exposure to Al. Experiment 1 (Lower level) rats were treated orally for 60 days: a) controls – ultrapure water; b) aluminum at 1.5 mg/kg bw/day and c) aluminum at 8.3 mg/kg bw/day. Experiment 2 (High level) rats were treated for 42 days: a) controls – ultrapure water; b) aluminum at 100 mg/kg bw/day. Al decreased sperm count, daily sperm production, sperm motility, normal morphological sperm, impaired testis histology; increased oxidative stress in reproductive organs and inflammation in testis. Our study shows the specific presence of Al in the germinative cells and, that low concentrations of Al in testes (3.35 μg/g) are sufficient to impair spermatogenesis and sperm quality. Our findings provide a better understanding of the reproductive health risk of Al.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at http://dx.doi.org/10.1016/j.reprotox.2017.08.008 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: metal, reproductive adverse effects, sperm quality
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculty of Natural Sciences > School of Life Sciences
Depositing User: Symplectic
Date Deposited: 18 Aug 2017 10:40
Last Modified: 18 Aug 2017 10:43
URI: http://eprints.keele.ac.uk/id/eprint/3913

Actions (login required)

View Item View Item