Keele Research Repository

Edelstyn, NMJ, Shepherd, TA, Mayes, AR, Sherman, SM and Ellis, SJ (2011) Effects of L-Dopa and Dopamine D2 Agonists on Recollection and Familiarity in Idiopathic Nondementing Parkinson’s Disease. Neuroscience and Medicine, 2 (4). 318 -329. ISSN 2158-2947

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Abstract

Idiopathic nondementing Parkinson’s disease (PD) is marked by progressive loss of dopaminergic neurons in the substantia nigra pars compacta and ventral tegmental area. Recent brain imaging work implicates these structures in dopamine modulated networks subserving episodic memory. These findings are of relevance to PD because they suggest that dopamine depletion contributes to the disease-dependent decline in episodic memory, and therefore, this decline should, at least partially, be remediated by dopaminergic medication. Recognition memory (RM), recollection and familiarity during recognition was examined in 17 PD patients, 12 of whom were medicated with a D2 dopamine agonist (pramipexole or ropinirole) and l-dopa, with a further 5 PD control patients on l-dopa but no D2 agonist. Memory was tested “ON” and, following a period of medication withdrawal, “OFF” and compared to a group of 14 matched healthy volunteers (HV). The HVs were also tested twice in the absence of medication. The patients on the agonists PD showed significant impairments in recollection ON- and OFF-medication, whereas the l-dopa control patients exhibited a decline in OFF-recollection only. RM and familiarity were spared in both groups ON- and OFF-medication. These findings suggest that D2 dopamine agonists (combined with l-dopa) contribute to disease-dependent episodic memory impairment.

Item Type:	Article
Additional Information:	This is the final published version of the article (version of record). It first appeared online via Scientific Research Publishing at http://dx.doi.org/10.4236/nm.2011.24042 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords:	Parkinson’s Disease, D2 Dopamine Agonists, L-Dopa, Recognition, Recollection, Familiarity
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Divisions:	Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User:	Symplectic
Date Deposited:	29 Aug 2017 15:23
Last Modified:	22 Aug 2018 14:18
URI:	http://eprints.keele.ac.uk/id/eprint/3952

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