Edelstyn, NMJ, Martini, A ORCID: 0000-0002-6349-0831, Ellis, SJ, Grange, JA, Tamburin, S, Vianello, G and Dal Lago, D (2018) Risky Decision-Making And Affective Features Of Impulse Control Disorders In Parkinson’s Disease. Journal of Neural Transmission, 125 (2). pp. 131-143. ISSN 0300-9564

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Abstract

Background. Impulse Control Disorders (ICDs) in Parkinson’s disease (PD) are considered dopaminergic treatment side effects. Cognitive and affective factors may increase the risk of ICD in PD.
Aims. To investigate risky decision-making and associated cognitive processes in PD patients with ICDs within a four-stage conceptual framework. Relationship between ICDs and affective factors was explored.
Methods. Thirteen PD patients with ICD (ICD+), 12 PD patients without ICD (ICD-) and 17 healthy controls were recruited. Overall risky decision-making and negative feedback effect were examined with The Balloon Analogue Risk Task (BART). A cognitive battery dissected decision-making processes according to the four-stages conceptual framework. Affective and motivational factors were measured.
Results. ANOVA showed no effect of group on overall risky decision-making. However, there was a group x feedback interaction [F (2, 39) = 3.31, p = 0.047]. ICD+, unlike ICD- and healthy controls, failed to reduce risky behaviour following negative feedback. A main effect of group was found for anxiety and depression [F(2, 38) = 8.31, p = 0.001], with higher symptoms in ICD+ vs. healthy controls. Groups did not differ in cognitive outcomes or affective and motivational metrics.
Conclusions. ICD+ may show relatively preserved cognitive function, but reduced sensitivity to negative feedback during risky decision-making and higher symptoms of depression and anxiety.

Item Type: Article
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: Parkinson’s disease, impulse control disorders, decision-making, cognition, affective factors, mood
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Divisions: Faculty of Natural Sciences > School of Psychology
Depositing User: Symplectic
Date Deposited: 01 Nov 2017 16:03
Last Modified: 12 Nov 2018 09:35
URI: http://eprints.keele.ac.uk/id/eprint/4159

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