Morgan, E (2015) Discovery of a series of 2-(pyridinyl) pyrimidines as potent antagonists of GPR40. MedChemComm, 6 (6). pp. 1024-1029.

[img]
Preview
Text
David Morgan - Discovery of a series of 2-(pyridinyl)pyrimidines as potent antagonists of GPR40.pdf

Download (932kB) | Preview

Abstract

A series of 2-(pyridinyl)pyrimidines were identified as potent GPR40 antagonists. Despite significant challenges related to improving the combination of potency and lipophilicity within the series, the compounds were optimised to identify a suitable in vivo probe compound, which was confirmed to exhibit pharmacology consistent with GPR40 antagonism.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Physical and Geographical Sciences
Depositing User: Symplectic
Date Deposited: 22 Apr 2015 11:07
Last Modified: 02 May 2019 11:26
URI: http://eprints.keele.ac.uk/id/eprint/417

Actions (login required)

View Item View Item