Jones, K and Linhart, C and Hawkins, C and Exley, C (2017) Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis. EBioMedicine. ISSN 2352-3964

[img]
Preview
Text
exley_ebiomed_2017.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (683kB) | Preview

Abstract

AbstractBackground Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete unusually high amounts of aluminium in their urine. Silicon-rich mineral waters facilitate the removal of aluminium from the body in urine and herein we have tested their efficacy in affecting urinary excretion of aluminium in individuals diagnosed with secondary progressive multiple sclerosis (SPMS). Methods Urinary excretion of aluminium and silicon, measured using transversely-heated graphite furnace atomic absorption spectrometry, was determined in 15 individuals diagnosed with SPMS over 24 weeks, a 12 week baseline period (control) followed by a 12 week treatment period, during which individuals consumed up to 1.5 L of a silicon-rich mineral water every day. Findings Individuals with SPMS excreted high amounts of aluminium during the baseline period (135.2 nmol/mmol Crt (70.3–222.2, n = 180) and females excreted significantly more aluminium than males. Regular drinking of a silicon-rich mineral water increased the urinary excretion of aluminium significantly (349.0 nmol/mmol Crt (231.7–524.7, n = 180; three-way ANOVA, F1,13 = 59.17, p-value = 0.000003) relative to the baseline period. The majority of individuals, 14 out of 15, excreted more aluminium (μmol/24 h) following drinking of a silicon-rich mineral water (independent-test, p < 0.05). Silicon-rich mineral waters may be an effective and non-invasive therapy for the removal of aluminium from the body of individuals with SPMS.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/j.ebiom.2017.10.028 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: secondary progressive multiple sclerosis, aluminium and human health, silicon-rich mineral water, urinary aluminium excretion, Urinary silicon excretion, non-invasive therapy
Subjects: R Medicine > RC Internal medicine > RC346 Neurology. Diseases of the nervous system, including speech disorders
Depositing User: Symplectic
Date Deposited: 02 Nov 2017 14:30
Last Modified: 02 Nov 2017 15:53
URI: http://eprints.keele.ac.uk/id/eprint/4170

Actions (login required)

View Item View Item