Moss, DM and Curley, P and Kinvig, H and Hoskins, C and Owen, A (2017) The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery. Expert Review of Gastroenterology and Hepatology. ISSN 1747-4132

[img] Text
Main text blinded.docx - Accepted Version
Restricted to Repository staff only until 8 November 2018.
Available under License Creative Commons Attribution Non-commercial.

Download (231kB)

Abstract

Introduction
Nano-scale formulations are being developed to improve the delivery of orally administered medicines, and the interactions between nanoformulations and the gastrointestinal luminal, mucosal and epithelial environment is currently being investigated. The mucosal surface of the gastrointestinal tract is capable of trapping and eliminating large particles and pathogens as part of the natural defences of the body, it is becoming clearer that nanoformulation properties such as particle size, charge, and shape, as well as mucous properties such as viscoelasticity, thickness, density, and turn-over time are all relevant to these interactions. However, progress has been slow to utilise this information to produce effective mucous-penetrating particles.

Areas covered
This review focuses on delivery method of nanomedicines both into and across the gastrointestinal mucosal surface, and aims to summarise the biological barriers that exist to successful oral nanomedicine delivery and how these barriers may be investigated and overcome.

Expert commentary
Despite successes in the laboratory, no nanotechnology-enabled products are currently in clinical use which either specifically target the intestinal mucous surface or cross the epithelial barrier intact. New nanomedicine-based treatments of local diseases (intestinal cancer, inflammation, infection) and systemic diseases are advancing towards clinical use, and offer genuine opportunities to improve therapy.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Taylor & Francis at http://dx.doi.org/10.1080/17474124.2018.1399794 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: nanomedicine, intestine, mucous, targeted drug delivery, mucoadhesion
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine and Health Sciences > School of Pharmacy
Depositing User: Symplectic
Date Deposited: 09 Nov 2017 12:03
Last Modified: 09 Nov 2017 12:03
URI: http://eprints.keele.ac.uk/id/eprint/4198

Actions (login required)

View Item View Item