Roddy, E, Mallen, CD and Belcher, J (2015) Gout and risk of chronic kidney disease and nephrolithiasis meta-analysis of observational studies. Arthritis Research and Therapy, 17 (90). ISSN 1478-6362

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Abstract

ntroduction
To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.

Methods
Systematic review and meta-analysis of epidemiological studies. Data sources; MEDLINE, EMBASE and CINAHL databases, hand-searched reference lists, citation history and contact with authors. Eligibility criteria: cohort, case–control or cross-sectional studies which examined the occurrence of chronic kidney disease or nephrolithiasis amongst adults with gout (with or without a non-gout comparator group) in primary care or general population samples. Prevalence and risk estimate meta-analyses were performed using a random-effects model.

Results
Seventeen studies were included in the meta-analysis (chronic kidney disease n = 7, nephrolithiasis n = 8, both n = 2). Pooled prevalence estimates of chronic kidney disease stage ≥3 and self-reported lifetime nephrolithiasis in people with gout were 24% (95% confidence interval 19% to 28%) and 14% (95% CI 12% to 17%) respectively. Gout was associated with both chronic kidney disease (pooled adjusted odds ratio 2.41, 95% confidence interval 1.86 to 3.11) and self-reported lifetime nephrolithiasis (1.77, 1.43 to 2.19).

Conclusions
Chronic kidney disease and nephrolithiasis are commonly found amongst patients with gout. Gout is independently associated with both chronic kidney disease and nephrolithiasis. Patients with gout should be actively screened for chronic kidney disease and its consequences.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via BioMed Central at https://doi.org/10.1186/s13075-015-0610-9 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: gout, kidney disease
Subjects: R Medicine > R Medicine (General)
Depositing User: Symplectic
Date Deposited: 22 Apr 2015 14:27
Last Modified: 18 Jun 2018 15:38
URI: http://eprints.keele.ac.uk/id/eprint/420

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