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An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device

O'Brien, M; Hall, A; Schrauwen, J; van der Made, J

An open-source approach to automation in organic synthesis: The flow chemical formation of benzamides using an inline liquid-liquid extraction system and a homemade 3-axis autosampling/product-collection device Thumbnail


Authors

A Hall

J Schrauwen

J van der Made



Abstract

Several open-source hardware and software technologies (RAMPS, Python, PySerial, OpenCV) were used to control an automated flow chemical synthesis system. The system was used to effect the synthesis of a series of benzamides. An inexpensive Raspberry Pi single board computer provided an electronic interface between the control computer and the RAMPS motor driver boards.

Acceptance Date Feb 19, 2018
Publication Date Feb 21, 2018
Publicly Available Date Mar 29, 2024
Journal Tetrahedron
Print ISSN 0040-4020
Publisher Elsevier
Pages 3152-3157
DOI https://doi.org/10.1016/j.tet.2018.02.043
Keywords Low-cost-automation; Open-source; Python; OpenCV; Raspberry-Pi; Flow-chemistry; Amide-formation; Liquid-liquid extraction
Publisher URL https://doi.org/10.1016/j.tet.2018.02.043