Cabrera, D, Coene, A, Leliaert, J, Artés-Ibáñez, EJ, Dupré, L, Telling, ND and Teran, FJ (2018) Dynamical Magnetic Response of Iron Oxide Nanoparticles Inside Live Cells. ACS Nano, 12 (3). pp. 2741-2752. ISSN 1936-086X

[img] Text
Cabrera-et-al-Manuscript- accepted manuscript.pdf - Accepted Version
Restricted to Repository staff only until 6 March 2019.
Available under License Creative Commons Attribution Non-commercial.

Download (1MB)

Abstract

Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. Recent studies suggest the enhancement of nanoparticle clustering and/or immobilization after interaction with cells as possible causes, although a quantitative description of the influence of biological matrices on the magnetic response of magnetic nanoparticles under AC magnetic fields is still lacking. Here, we studied the effect of cell internalization on the dynamical magnetic response of iron oxide nanoparticles (IONPs). AC magnetometry and magnetic susceptibility measurements of two magnetic core sizes (11 and 21 nm) underscored differences in the dynamical magnetic response following cell uptake with effects more pronounced for larger sizes. Two methodologies have been employed for experimentally determining the magnetic heat losses of magnetic nanoparticles inside live cells without risking their viability as well as the suitability of magnetic nanostructures for in vitro hyperthermia studies. Our experimental results-supported by theoretical calculations-reveal that the enhancement of intracellular IONP clustering mainly drives the cell internalization effects rather than intracellular IONP immobilization. Understanding the effects related to the nanoparticle transit into live cells on their magnetic response will allow the design of nanostructures containing magnetic nanoparticles whose dynamical magnetic response will remain invariable in any biological environments, allowing sustained and predictable in vivo heating efficiency.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version is available online via American Chemical Society at http://doi.org/10.1021/acsnano.7b08995 Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: dynamical magnetic response, live cells, magnetic hyperthermia, magnetic interactions, magnetic nanoparticles
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Related URLs:
Depositing User: Symplectic
Date Deposited: 27 Mar 2018 14:58
Last Modified: 27 Mar 2018 15:01
URI: http://eprints.keele.ac.uk/id/eprint/4662

Actions (login required)

View Item View Item