Ragazzon, P, McGown, A, Ragazzon-Smith, A, Hadfield, J and Potgetier, H (2018) Microwave Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents. Letters in Organic Chemistry. ISSN 1570-1786 (In Press)

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Abstract

In this study we describe a microwave based click chemistry method used to prepare a family of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked through a triazole ring. The compounds were easily synthesized and purified in high yields. The bis-flavonoids were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several analogues showed to have anticancer activity with IC50 values in the range of 20-60 µM. Flavonoids are known for their anticancer properties and this method provides the basis for new medicinal structures.

Item Type: Article
Subjects: Q Science > QD Chemistry
Depositing User: Symplectic
Date Deposited: 25 Jun 2018 15:50
Last Modified: 25 Jun 2018 15:50
URI: http://eprints.keele.ac.uk/id/eprint/5025

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