Yu, D ORCID: 0000-0002-8449-7725, Cai, Y, Qin, R, Graffy, J, Holman, D, Zhao, Z and Simmons, D (2018) Total / high-density lipoprotein cholesterol and cardiovascular disease (re)hospitalisation nadir in type 2 diabetes. Journal of Lipid Research, 59. pp. 1745-1750. ISSN 1539-7262

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Abstract

Total cholesterol to high density lipoprotein cholesterol ratio (TC/HDL) is an important prognostic factor for cardiovascular disease (CVD). This study used restricted cubic spline modelling to investigate the dose-response associations between TC/HDL and both CVD hospitalisation and CVD re-hospitalisation in two independent prospective cohorts. The East Cambridgeshire and Fenland (ECF) cohort includes 4,704 patients with type 2 diabetes from 18 general practices in Cambridgeshire. The RAndomised controlled trial of Peer Support In type 2 Diabetes (RAPSID) cohort comprises 1,121 patients with type 2 diabetes with post-trial follow-up data. TC/HDL and other demographic and clinical measurements were measured at baseline. Outcomes were CVD hospitalisation over 2 years, and CVD re-hospitalisation after 90 days of the prior CVD hospitalisation. Modelling showed nonlinear relationships between TC/HDL and risks of CVD hospitalisation and re-hospitalisation consistently in both cohorts (all P < 0.001 for linear tests). The lowest risks of CVD hospitalisation and re-hospitalisation were consistently found for TC/HDL at 2.8 (95% confidence interval: 2.6 to 3.0) in both cohorts and both overall and by gender. This is lower than the current lipid control target, 4.0 of TC/HDL. Reducing the TC/HDL target to 2.8 would include a further 33-44% patients with TC/HDL in the 2.8-4.0 range. Studies are required to assess the effectiveness and cost effectiveness of the earlier introduction of, and more intensive, lipid lowering treatment needed to achieve this new lower TC/HDL target.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via American Society for Biochemistry and Molecular Biology at http://doi.org/10.1194/jlr.P084269 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Diabetes population, Hospitalisation, re hospitalisation, TC/HDL, Lipid
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Depositing User: Symplectic
Date Deposited: 05 Jul 2018 10:56
Last Modified: 10 Sep 2018 14:23
URI: http://eprints.keele.ac.uk/id/eprint/5087

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