Fang, L, Trigiante, G, Kousseff, CJ, Crespo-Otero, R, Philpott, MP and Watkinson, M ORCID: 0000-0003-1877-5667 (2018) Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells. Chemical Communications (69). pp. 9619-9266. ISSN 1364-548X

[img] Text
Acceptedmanuscript.docx - Accepted Version
Restricted to Repository staff only until 10 August 2019.
Available under License Creative Commons Attribution Non-commercial.

Download (1MB)

Abstract

A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+ in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Royal Society of Chemistry at http://doi.org/10.1039/c8cc05425h - please refer to any applicable terms of use of the publisher.
Subjects: Q Science > QD Chemistry > QD415 Biochemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 22 Aug 2018 08:31
Last Modified: 10 Sep 2018 14:19
URI: http://eprints.keele.ac.uk/id/eprint/5232

Actions (login required)

View Item View Item