Shoaib, A, Kinnaird, T, Curzen, N, Kontopantelis, E, Ludman, P, de Belder, M, Rashid, M, Kwok, CS ORCID: 0000-0001-7047-1586, Nolan, J, Zaman, A and Mamas, MA ORCID: 0000-0001-9241-8890 (2018) Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass Grafts. Circulation: Cardiovascular Interventions. ISSN 1941-7632 (In Press)

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Abstract

Background: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national cohort. Methods & Results: We identified 205,039 patients with NSTEMI who underwent PCI between 2007-2014 in the British Cardiovascular Intervention Society (BCIS) database. Clinical, demographical, procedural and outcome data were analysed by dividing into three groups; Group 1- PCI in native coronary arteries and no prior CABG (n= 186,670), Group 2- PCI in native arteries with prior CABG (n= 8,825), Group 3- PCI in Grafts (n= 9,544). Patients in Group 2 & 3 were older, had more comorbidities and higher mortality at 30 days (group 2 -2.6%, group 3 – 1.9%) and 1 year (group 2 – 8.29%, group 3 – 7.08%) as compared to Group 1 (1.7% & 4.87%). Following multivariable analysis, no significant difference in outcomes were observed in 30 days mortality (OR: group 2 = 0.87 (CI 0.69-1.80, P-0.20), group 3 = 0.91 (CI 0.71-1.17, P-0.46)), in-hospital MACE (OR: group 2 = 1.08 (CI 0.88-1.34, P- 0.45), group 3 0.97 (CI 0.77-1.23, P- 0.82)) and in-hospital stroke (OR: group 2 = 1.37 (CI 0.71-2.69, P - 0.35), group 3 = 1.13 (CI 0.55-2.34, P- 0.73))(group 1= reference). Conclusion: Patients with prior CABG presenting with NSTEMI and treated with PCI had more co-morbid illnesses but once these differences were adjusted for, prior CABG did not independently confer additional risk of mortality and MACE. Keywords: PCI, NSTEMI, Mortality, Complications

Item Type: Article
Additional Information: This is the accepted author manuscript (AAM). The final published version (version of record) will be available online via American Heart Association at https://www.ahajournals.org/journal/circinterventions - please refer to any applicable terms of use of the publisher.
Subjects: R Medicine > RC Internal medicine > RC666 Diseases of the circulatory (Cardiovascular) system
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 14 Sep 2018 14:14
Last Modified: 14 Sep 2018 14:18
URI: http://eprints.keele.ac.uk/id/eprint/5318

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