Prabhu, DD, Aratsu, K, Kitamoto, Y, Ouchi, H, Ohba, T, Hollamby, MJ, Shimizu, N, Takagi, H, Haruki, R, Adachi, S-I and Yagai, S (2018) Self-folding of supramolecular polymers into bioinspired topology. Science Advances, 4 (9). eaat8466 - ?. ISSN 2375-2548

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Abstract

Folding one-dimensional polymer chains into well-defined topologies represents an important organization process for proteins, but replicating this process for supramolecular polymers remains a challenging task. We report supramolecular polymers that can fold into protein-like topologies. Our approach is based on curvature-forming supramolecular rosettes, which affords kinetic control over the extent of helical folding in the resulting supramolecular fibers by changing the cooling rate for polymerization. When using a slow cooling rate, we obtained misfolded fibers containing a minor amount of helical domains that folded on a time scale of days into unique topologies reminiscent of the protein tertiary structures. Thermodynamic analysis of fibers with varying degrees of folding revealed that the folding is accompanied by a large enthalpic gain. The self-folding proceeds via ordering of misfolded domains in the main chain using helical domains as templates, as fully misfolded fibers prepared by a fast cooling rate do not self-fold.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via American Association for the Advancement of Science at http://doi.org/10.1126/sciadv.aat8466 - please refer to any applicable terms of use of the publisher.
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 17 Sep 2018 14:43
Last Modified: 17 Sep 2018 14:49
URI: http://eprints.keele.ac.uk/id/eprint/5320

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