Mold, M, Chmielecka, A, Rodriguez, MRR, Thom, F, Linhart, C, King, A and Exley, C ORCID: 0000-0002-5116-7607 (2018) Aluminium in Brain Tissue in Multiple Sclerosis. International Journal of Environmental Research and Public Health, 15 (8). ISSN 1660-4601

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Abstract

Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via MDPI AG at http://doi.org/10.3390/ijerph15081777 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: TH GFAAS, aluminium-specific fluorescence, human brain tissue, human exposure to aluminium, multiple sclerosis
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 17 Sep 2018 15:26
Last Modified: 17 Sep 2018 15:30
URI: http://eprints.keele.ac.uk/id/eprint/5323

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