Bursill, D, Taylor, WJ, Terkeltaub, R, Kuwabara, M, Merriman, TR, Grainger, R, Pineda, C, Louthrenoo, W, Edwards, NL, Andrés, M, Vargas-Santos, AB, Roddy, E, Pascart, T, Lin, C-T, Perez-Ruiz, F, Tedeschi, SK, Kim, SC, Harrold, LR, McCarthy, G, Kumar, N, Chapman, PT, Tausche, A-K, Vazquez-Mellado, J, Gutierrez, M, Pinheiro, GDRC, Richette, P, Pascual, E, Fisher, MC, Burgos-Vargas, R, Robinson, PC, Singh, JA, Jansen, TL, Saag, KG, Slot, O, Uhlig, T, Solomon, DH, Keenan, RT, Scire, CA, Biernat-Kaluza, E, Dehlin, M, Nuki, G, Schlesinger, N, Janssen, M, Stamp, LK, Sivera, F, Reginato, AM, Jacobsson, L, Lioté, F, Ea, H-K, Rosenthal, A, Bardin, T, Choi, HK, Hershfield, MS, Czegley, C, Choi, SJ and Dalbeth, N (2018) Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) consensus statement regarding labels and definitions for disease elements in gout. Arthritis Care Res (Hoboken). ISSN 2151-4658

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Abstract

OBJECTIVE: The language currently used to describe gout lacks standardisation. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout. METHODS: Experts in gout (n=130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labelling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting. RESULTS: There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of eight disease elements through the Delphi exercise; the remaining three labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were: monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion and podagra. The face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label 'chronic gout' should not be used. CONCLUSION: Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout aetiology, pathophysiology and clinical presentation. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) recommends the use of these labels when describing the basic disease elements of gout. This article is protected by copyright. All rights reserved.

Item Type: Article
Uncontrolled Keywords: gout, nomenclature, terminology, urate
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Sep 2018 14:30
Last Modified: 18 Sep 2018 14:30
URI: http://eprints.keele.ac.uk/id/eprint/5329

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