Marshall, I, Thrippleton, MJ, Bastin, ME, Mollison, D, Dickie, DA, Chappell, FM, Semple, SIK, Cooper, A, Pavitt, S, Giovannoni, G, Wheeler-Kingshott, CAMG, Solanky, BS, Weir, CJ, Stallard, N, Hawkins, C, Sharrack, B, Chataway, J, Connick, P, Chandran, S and MS-SMART Trialists, . (2018) Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis: a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265 (8). 1795 - 1802. ISSN 1432-1459

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Abstract

Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not consistent with the usual assumption of 'chronic' lesions in SPMS, and may represent a target for repair therapies.

Item Type: Article
Additional Information: © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords: Brain metabolites, Magnetic resonance spectroscopy, Multiple sclerosis, Normal-appearing white matter, White matter lesions
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC925 Diseases of the musculoskeletal system
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
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Depositing User: Symplectic
Date Deposited: 19 Sep 2018 09:03
Last Modified: 19 Sep 2018 09:03
URI: http://eprints.keele.ac.uk/id/eprint/5332

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