Corns, LF, Johnson, SL, Roberts, T, Ranatunga, KM, Hendry, A, Ceriani, F, Safieddine, S, Steel, KP, Forge, A, Petit, C, Furness, DN, Kros, CJ and Marcotti, W (2018) Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature Communications, 9. ISSN 2041-1723

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Abstract

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are open, resulting in a sustained depolarizing current. By genetically manipulating the in vivo expression of molecular components of the MET apparatus, we show that during pre-hearing stages the MET current is essential for establishing the electrophysiological properties of mature inner hair cells (IHCs). If the MET current is abolished in adult IHCs, they revert into cells showing electrical and morphological features characteristic of pre-hearing IHCs, including the re-establishment of cholinergic efferent innervation. The MET current is thus critical for the maintenance of the functional properties of adult IHCs, implying a degree of plasticity in the mature auditory system in response to the absence of normal transduction of acoustic signals.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Nature at http://doi.org/10.1038/s41467-018-06307 - please refer to any applicable terms of use of the publisher.
Subjects: Q Science > QH Natural history
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 18 Oct 2018 15:29
Last Modified: 18 Oct 2018 15:31
URI: http://eprints.keele.ac.uk/id/eprint/5428

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