Moise, S, Byrne, JM, El Haj, AJ and Telling, ND (2018) The potential of magnetic hyperthermia for triggering the differentiation of cancer cells. Nanoscale, 10 (44). pp. 20519-20525. ISSN 2040-3372

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Abstract

Magnetic hyperthermia is a potential technique for cancer therapy that exploits heat generated by magnetic nanoparticles to kill cancerous cells. Many studies have shown that magnetic hyperthermia is effective at killing cancer cells both in vitro and in vivo, however little attention has been paid to the cellular functioning of the surviving cells. We report here new evidence demonstrating the onset of thermally triggered differentiation in osteosarcoma cancer cells that survive magnetic hyperthermia treatment. This raises the possibility that in addition to causing cell death, magnetic hyperthermia could induce surviving cancer cells to form more mature cell types and thereby inhibit their capacity to self-renew. Such processes could prove to be as important as cell death when considering magnetic hyperthermia for treating cancer.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Royal Society of Chemistry at http://doi.org/10.1039/c8nr05946b - please refer to any applicable terms of use of the publisher.
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
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Depositing User: Symplectic
Date Deposited: 12 Nov 2018 10:24
Last Modified: 06 Dec 2018 12:20
URI: http://eprints.keele.ac.uk/id/eprint/5499

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