Shardlow, E, Mold, M and Exley, C ORCID: 0000-0002-5116-7607 (2018) Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action. Allergy Asthma and Clinical Immunology, 14. ISSN 1710-1484

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Abstract

Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and AdjuPhos®, while the novel aluminium adjuvant used in Gardasil® is a sulphated version of the latter. We have investigated the physicochemical properties of these two aluminium adjuvants and specifically in milieus approximating to both vaccine vehicles and the composition of injection sites. Additionally we have used a monocytic cell line to establish the relationship between their physicochemical properties and their internalisation and cytotoxicity. We emphasise that aluminium adjuvants used in clinically approved vaccines are chemically and biologically dissimilar with concomitantly potentially distinct roles in vaccine-related adverse events.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via BioMed Central at http://dx.doi.org/10.1186/s13223-018-0305-2 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: immunology
Subjects: Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculty of Natural Sciences > School of Life Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 23 Nov 2018 11:04
Last Modified: 23 Nov 2018 11:05
URI: http://eprints.keele.ac.uk/id/eprint/5522

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