Dorrington, S, Zavos, H, Ball, H, McGuffin, P, Sumathipala, A, Siribaddana, S, Rijsdijk, F, Hatch, SL and Hotopf, M (2019) Family functioning, trauma exposure and PTSD: A cross sectional study. Journal of Affective Disorders, 245. 645 -652.

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Abstract

OBJECTIVE:
Only a minority of trauma-exposed individuals go on to develop post traumatic stress disorder (PTSD). Previous studies in high income countries suggest that maladaptive family functioning adversities (MFFA) in childhood may partially explain individual variation in vulnerability to PTSD following trauma. We test in a lower middle-income setting (Sri Lanka) whether: (1) MFFA is associated with trauma exposure; (2) MFFA moderates the association between exposure to trauma and later (a) PTSD (b) other psychiatric diagnoses; and (3) any association between MFFA and PTSD is explained by experiences of interpersonal violence, cumulative trauma exposure or comorbid psychopathology.

METHODS:
We conducted a population study of 3995 twins and 2019 singletons residing in Colombo, Sri Lanka. Participants completed the Composite International Diagnostic Interview, including nine traumatic exposures and a questionnaire on MFFA. RESULTS: 23.4% of participants reported exposure to MFFA. We found that (1) MFFA was strongly associated with trauma exposure (2) MFFA moderates the association between trauma exposure and both (a) PTSD and (b) other DSM psychiatric diagnosis. (3) This was not explained by interpersonal violence, cumulative trauma exposure or other psychopathology.

CONCLUSIONS:
MFFA moderates the association between trauma and PTSD, and the association between trauma and non-PTSD psychopathology.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Elsevier at http://doi.org/10.1016/j.jad.2018.11.056 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: trauma exposure, PTSD
Subjects: R Medicine > R Medicine (General)
R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine and Health Sciences > Primary Care Health Sciences
Related URLs:
Depositing User: Symplectic
Date Deposited: 10 Dec 2018 15:44
Last Modified: 06 Mar 2019 15:31
URI: http://eprints.keele.ac.uk/id/eprint/5569

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