Naire, S, Campbell, K and Kuiper, JH (2019) A mathematical model of cartilage regeneration after chondrocyte and stem cell implantation - II: The effects of co-implantation. Journal of Tissue Engineering, 10. pp. 1-14.

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Abstract

We present a mathematical model of cartilage regeneration after cell therapy, to show how co-implantation of stem cells (mesenchymal stem cells) and chondrocytes into a cartilage defect can impact chondral healing. The key mechanisms involved in the regeneration process are simulated by modelling cell proliferation, migration and differentiation, nutrient diffusion and Extracellular Matrix (ECM) synthesis at the defect site, both spatially and temporally. In addition, we model the interaction between mesenchymal stem cells and chondrocytes by including growth factors. In Part I of this work, we have shown that matrix formation was enhanced at early times when mesenchymal stem cell-to-chondrocyte interactions due to the effects of growth factors were considered. In this article, we show that the additional effect of co-implanting mesenchymal stem cells and chondrocytes further enhances matrix production within the first year in comparison to implanting only chondrocytes or only mesenchymal stem cells. This could potentially reduce healing time allowing the patient to become mobile sooner after surgery.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via SAGE at https://doi.org/10.1177/2041731419827792 - Please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: Mathematical modelling, cartilage defect, regenerative medicine, co-culture, mesenchymal stem cells
Subjects: Q Science > QA Mathematics
R Medicine > R Medicine (General)
Divisions: Faculty of Natural Sciences > School of Computing and Maths
Depositing User: Symplectic
Date Deposited: 04 Jan 2019 11:09
Last Modified: 01 Apr 2019 08:28
URI: http://eprints.keele.ac.uk/id/eprint/5616

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