Mahboob, Alam (1968) Synthetic studies in tecoma stans alkaloids and related compounds. Doctoral thesis, Keele University.

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Abstract

The chemistry of Tecoma stans and cyclopentanoid monoterpene alkaloids is reviewed. A brief review of the chemistry of the related compounds and of 9-azasteroids is also included.
Several methods for the construction of a perhydropyrindane system have been investigated.
A synthesis of 2:4-dimethyl-l:2:3:4:5:7-hexahydro-6H-2-pyrindin-2-one is given, together with the syntheses of l:5-dimethyl-3-carboethoxy-4-piperidone and N-phenyl-3-carbomethoxy-4-piperidone.
Alkylation of the basic keto-esters (e.g. 1:5-dimethyl-3-carbo­ethoxy-4-piperidone) has been achieved in higher yields than reported in the literature.
A synthesis of 1:5-dimethyl-3-cyanomethyl-4-piperidone and its conversion to 1:5-dimethyl-3-cyanomethyl-4-chloropiperidine is described together with a synthesis of the ethylene ketal of N-methyl-3-carboethoxy­methyl-4-piperidone.

Item Type: Thesis (Doctoral)
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Natural Sciences > School of Chemical and Physical Sciences
Depositing User: Lisa Bailey
Date Deposited: 11 Jan 2019 12:59
Last Modified: 11 Jan 2019 12:59
URI: http://eprints.keele.ac.uk/id/eprint/5674

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