Al-Tameemi, W ORCID: 0000-0002-4408-3288 and Forsyth, NR ORCID: 0000-0001-5156-4824 (2019) Hypoxia-modified cancer cell metabolism. Frontiers in Cell and Developmental Biology. ISSN 2296-634X

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Abstract

While oxygen is critical to the continued existence of complex organisms, extreme levels of oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive levels of oxygen), potentially promote stress within a defined biological environment. The consequences of tissue hypoxia, a result of a defective oxygen supply, vary in response to the gravity, extent and environment of the malfunction. Persistent pathological hypoxia is incompatible with normal biological functions, and as a result, multicellular organisms have been compelled to develop both organism-wide and cellular-level hypoxia solutions. Both direct, including oxidative phosphorylation down-regulation and inhibition of fatty-acid desaturation, and indirect processes, including altered hypoxia-sensitive transcription factor expression, facilitate the metabolic modifications that occur in response to hypoxia. Due to the dysfunctional vasculature associated with large areas of some cancers, sections of these tumors continue to develop in hypoxic environments. Crucial to drug development, a robust understanding of the significance of these metabolism changes will facilitate our understanding of cancer cell survival. This review defines our current knowledge base of several of the hypoxia-instigated modifications in cancer cell metabolism and exemplifies the correlation between metabolic change and its support of the hypoxic-adapted malignancy.

Item Type: Article
Additional Information: This is the final published version of the article (version of record). It first appeared online via Frontiers Media at https://doi.org/10.3389/fcell.2019.00004 - please refer to any applicable terms of use of the publisher.
Uncontrolled Keywords: hypoxia, metabolism, Warburg effect, HIF, Glut-1, glycolysis, mitochondria
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine and Health Sciences > Institute for Science and Technology in Medicine
Depositing User: Symplectic
Date Deposited: 31 Jan 2019 12:11
Last Modified: 31 Jan 2019 12:48
URI: http://eprints.keele.ac.uk/id/eprint/5733

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